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Which one of the following classes of antibacterial drugs listed below does not target peptidoglycan synthesis?


A) penicillin
B) quinolones
C) ampicillin
D) vancomycin
E) cephalosporin

F) C) and D)
G) None of the above

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Subunit vaccines are generally considered safer than attenuated vaccines because …


A) subunit vaccines do not require booster shots.
B) attenuated vaccines may permit viral growth and possible mutation.
C) attenuated vaccines only elicit a humoral immune response.
D) attenuated vaccines elicit a weak immune response.
E) subunit vaccines elicit both a humoral and cell-mediated immune response.

F) C) and D)
G) B) and D)

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Bloodletting,or the intentional draining of blood from an ill individual,was a method commonly used in the middle ages to cure disease.

A) True
B) False

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Which one of the following classes of antibacterial drugs listed below does not target the 30S ribosomal subunit activities?


A) tetracycline
B) doxycycline
C) oxytetracycline
D) carbomycin
E) all target the 30S ribosomal subunit

F) C) and E)
G) D) and E)

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The original polio vaccine developed by Jonas Salk in 1952 was a(an) …


A) subunit vaccine.
B) acellular vaccine.
C) killed virus vaccine.
D) attenuated virus vaccine.
E) conjugate vaccine.

F) A) and B)
G) B) and E)

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Which of these factors led to the occurrence of plagues (epidemics of disease) in human society? (Select all that apply)


A) Overall populations as large as those seen today
B) Domestication of animals
C) Travel to new parts of the world (and return home)
D) Establishment of towns
E) Bloodletting

F) C) and D)
G) A) and D)

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Unlike bacteria,viruses do not develop resistance to antiviral drugs.

A) True
B) False

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Which vaccines are CDC-recommended for adults over 65 years of age? (Select all that apply)


A) Influenza
B) Polio
C) MMR
D) Varicella
E) Pneumococcal

F) None of the above
G) B) and D)

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Which one of the following classes of antibacterial drugs listed below does not target protein synthesis?


A) aminoglycosides
B) macrolides
C) tetracylcines
D) rifamycins
E) chloramphenicols

F) C) and D)
G) B) and C)

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Methicillin resistant Staphylococcus aureus (MRSA) has acquired the mecA gene from an unknown source.This gene encodes for a methicillin resistant …


A) efflux protein.
B) penicillin-binding protein.
C) β-lactamase.
D) acetyltransferase.
E) porin.

F) B) and C)
G) A) and B)

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The use of antibiotics in farm animals is believed to be a major contributor to the increased number of antibiotic resistant microbes observed in human infections.

A) True
B) False

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Which of these curative methods was NOT employed in past centuries?


A) Bloodletting
B) Use of purgatives
C) Religious procedures such as exorcisms
D) Use of herbal remedies
E) Administration of purified molecular compounds

F) B) and D)
G) A) and B)

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The enzyme chloramphenicol _______________ is encoded by a gene commonly found on some R-plasmids and covalently modifies chloramphenicol so it can longer bind to its target site.


A) phophoryltransferase
B) hydrolase
C) dehydrogenase
D) isomerase
E) acetyltransferase

F) C) and D)
G) B) and C)

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The smallpox Vaccinia virus was a(n)________________ vaccine.

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attenuated...

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An environment becomes more crowded with people and improved water lines and sewer lines are constructed within the area.What do you predict in terms of the impact of these two changes? (Select all that apply)


A) both will contribute to increased disease risk
B) neither will contribute to increased disease risk
C) increased population is a detrimental risk factor,enhanced separation of drinking and waster water is an improvement so overall disease risk will depend upon mode of disease transmission
D) increased population is not a detrimental risk factor,but separation of drinking and waster water is detrimental,so disease risk will depend upon mode of disease transmission
E) the incidence of airborne disease spread will likely increase

F) B) and C)
G) A) and E)

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Which vaccines are CDC-recommended for 2 year old children? (Select all that apply)


A) Influenza
B) Polio
C) MMR
D) Varicella
E) Pneumococcal

F) A) and B)
G) A) and C)

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All of the following are approaches used to help reduce the incidence of antimicrobial drug resistance except …


A) the use of very high concentrations of the drug.
B) use of a narrow spectrum antibiotic to treat a specific infection.
C) use of a combination of antibiotics.
D) good hygiene,such as frequent hand washing to prevent the spread of drug resistant microbes.
E) the use of antibiotics only when absolutely necessary.

F) B) and C)
G) A) and E)

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Which vaccines are recommended yearly? (Select all that apply)


A) Influenza
B) Diphtheria,tetanus,pertussis
C) MMR
D) Varicella
E) Pneumococcal

F) A) and E)
G) A) and C)

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A hypothetical vaccine has a 2% "failure rate".It has been administered to all but 12 children in a school with 1000 students.The disease the vaccine is designed to prevent is introduced by a new student and spreads rapidly via the respiratory route.How many children do you predict will fall ill by catching the diease from the sick child?


A) 12
B) 10
C) 20
D) 32
E) 120

F) All of the above
G) B) and D)

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The two most common ways drug resistant bacteria may develop in a person taking an antimicrobial drug are :


A) the bacteria acquire an R-plasmid during this period of time and some of the bacteria developed a resistance mutation.
B) the bacteria acquire an R-plasmid during this period of time and the person may be immunocompromised.
C) some of the bacteria develop a resistance mutation and the person may be immunocompromised.
D) the person may be immunocompromised and the person did not properly take the antimicrobial drug.
E) the person did not properly take the antimicrobial drug and some of the bacteria developed a resistance mutation.

F) A) and C)
G) All of the above

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